Li LAB Recording and decoding cell fate choice

Publications

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L. Li#, S. Bowling#, H. Lin, D. Chen, S.-W. Wang, F. D. Camargo, DARLIN mouse for in vivo lineage tracing at high efficiency and clonal diversity. Nature Protocols, doi: 10.1038/s41596-025-01141-z (2025).

M. Chen#, R. Fu#, Y. Chen, L. Li*, S.-W. Wang*, High-resolution, noninvasive single-cell lineage tracing in mice and humans based on DNA methylation epimutations. Nature Methods, doi: 10.1038/s41592-024-02567-1 (2025).

L. Li, S. Bowling, S. E. McGeary, Q. Yu, B. Lemke, K. Alcedo, Y. Jia, X. Liu, M. Ferreira, A. M. Klein, S.-W. Wang*, F. D. Camargo*, A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells. Cell 186, 5183-5199.e22 (2023). Research highlight in Nature Methods: Tang, L. Greater diversity for lineage tracing. Nat Methods 20, 1872 (2023).

L. Li#, L. Li#, Q. Li#, X. Liu#, X. Ma#, J. Yong, S. Gao, X. Wu, Y. Wei, X. Wang, W. Wang, R. Li, J. Yan, X. Zhu, L. Wen, J. Qiao, L. Yan*, F. Tang*, Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution. Cell Research 31, 463–477 (2020).

L. Li#, J. Dong#, L. Yan#, J. Yong, X. Liu, Y. Hu, X. Fan, X. Wu, H. Guo, X. Wang, X. Zhu, R. Li, J. Yan, Y. Wei, Y. Zhao, W. Wang, Y. Ren, P. Yuan, Z. Yan, B. Hu, F. Guo, L. Wen, F. Tang*, J. Qiao*, Single-cell RNA-seq analysis maps development of human germline cells and gonadal niche interactions. Cell Stem Cell 20, 858-873.e4 (2017).

R. Wang#, X. Liu#, L. Li#, M. Yang, J. Yong, F. Zhai, L. Wen, L. Yan, J. Qiao*, F. Tang*, Dissecting human gonadal cell lineage specification and sex determination using a single-cell RNA-seq approach. Genomics Proteomics Bioinformatics 20, 223–245 (2022).

S. H. Patel, C. Christodoulou, C. Weinreb, Q. Yu, E. L. da Rocha, B. J. Pepe-Mooney, S. Bowling, L. Li, F. Osorio, G. Daley, F. Camargo, Lifelong multilineage contribution by embryonic-born blood progenitors. Nature 606, 747–753 (2022).

Q. Ji#, Y. Zheng#, G. Zhang, Y. Hu, X. Fan, Y. Hou, L. Wen, L. Li, Y. Xu, Y. Wang*, F. Tang*, Single-cell RNA-seq analysis reveals the progression of human osteoarthritis. Annals of the rheumatic diseases 78, 100–110 (2019).